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Systematic literature review traumatic brain injury

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Traumatic brain injuries TBI are a significant cause of mortality and morbidity for children globally. Adherence to evidence-based treatment guidelines have been shown to improve TBI outcomes. To inform the creation of a pediatric TBI management guideline for a low and middle income country context, we assessed the quality of available clinical practice guidelines CPGs for the acute management pediatric TBI. These articles were screened by four reviewers independently. A reference and citation analysis was performed.
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Return to work after traumatic brain injury: Systematic review

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Oculomotor-Based Vision Assessment in Mild Traumatic Brain Injury: A Systematic Review

Aim and objective: To review, systematically, factors contributing to outcomes in patients with traumatic brain injury. Background: Traumatic brain injury is a leading cause of death and disability. Several studies have determined the significant predictors of outcomes after traumatic brain injury. The comprehensive identification of these reliable factors for traumatic brain injury is critical to both clinical practice and research. Design: Systematic literature review. Methods: Eligible studies that combined at least two variables to predict outcomes in patient with traumatic brain injury were identified via electronic database searches, footnote chasing and contact with clinical experts.
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Systematic review of depression in mild traumatic brain injury: study protocol

Objective: To review the literature addressing the assessment and management of pain in patients with polytraumatic injuries including traumatic brain injury TBI and blast-related headache, and to identify patient, clinician and systems factors associated with pain-related outcomes. Design: Systematic review. Due to a limited number of studies using controls or comparators, we included observational and rigorous qualitative studies. We systematically rated the quality of systematic reviews, cohort, and case-control design studies. Results: One systematic review, 93 observational studies, and one qualitative research study met inclusion criteria.
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Many concerns have centered in on the possible links between repeated concussions and chronic traumatic encephalopathy or CPE. A signature feature of the disease is abnormal deposits of a protein called tau that accumulates around small blood vessels in brain crevices. Researchers believe that multiple blows to the head may dislodge the tau protein from the cell structure and cause it to form in clumps inside nerve cells. Closed head injuries are a type of traumatic brain injury in which the skull and dura mater remain intact.
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